Some of the speakers from 'Low Carbohydrate International All Stars 2021' address questions from the audience. Including Dr. Paul Mabry, Dr. Brian Lenzkes, Dr. Tro Kalanjan, Dr. Robert Cywes and Dr. Richard Bernstein.
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Low Carb International All Stars 2021 – Denver Q&A Session
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Some of the many benefits of fasting on the immune system, blood pressure, blood sugar and anti-aging, all backed up by clinical data:
Thymus stem cells are regenerated, which suppresses aging and renews the immune system.
Fasting stimulates phagocytosis, the ingestion of bacteria and viruses by the immune system.
Blood pressure is quickly and dramatically lowered, which is very important for a good outcome with the current pandemic.
Fasting increases nitric oxide, which has manifold postive effects like reducing arterial plaque.
Weight loss from fasting only loses10% lean tissue and 90% fat compared to the typical 25% lean tissue and 75% fat lost when calorically restricting for long periods.
Blood clotting is reduced and blood clots and arterial plaque are reabsorbed into the body.
Vitamin D plasma levels are increased, and vitamin D in turn increases autophagy!
Blood sugar and insulin are lowered, allowing white blood cells to move more freely throughout the body and do their job. Ideal blood sugar is around 80. Some viruses activate glycolosis (the release of sugar in the body) and clinically it has been shown that decreasing glucose metabolism in the body weakens the influenza virus.
It’s absolutely fine for cortisol to be high while fasting, because it produces sugar from fat instead of lean tissue https://www.youtube.com/watch?v=giEDadzoErs
The hormone Leptin is an immunomodulator that keeps the body from attacking itself and obesity causes leptin resistance. Fasting very quickly reduces leptin resistance and leptin levels and one day of fasting can cut your leptin levels in half and gets your immune system working properly again!
When you move out of MTOR your body shuts down the building blocks of the cell which are used to produce organelles and proteins. This means the mechanisms needed by viruses to replicate are by and large unavailable when you are in a deeply fasted state.
It stimulates the AMPK complex and activates autophagy. Autophagy (literally self eating) will cause cells to recycle foreign matter such as viruses and kill cancerous and senescent cells. AMPK does many helpful things in the body including activating the body’s antioxidant defenses.
Does fast burn muscle? In most cases no! https://www.youtube.com/watch?v=teQIaU6wp2o
Deep ketosis virtually eliminates chronic inflammation in the body. This can offset the life threatening symptoms of viral pneumonia which effectively kills you through inflammation. This also creates BHB ketones in your body, which also help your immune system and anti-oxidative system, especially in the brain. Ketones also provide an additional energy source during infection, which is critical when trying to fight off a bug. In fact you can have as much as three times the total energy available in your blood when you are in deep ketosis, or even more.
It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency and thereby making cells better able to fight off infection. Increased mitochondrial function also has the added benefit of increasing your metabolism and cancer prevention!
Fasts from 36-96 h actually INCREASE metabolic rate! https://www.youtube.com/watch?v=BeC_gIR2Z14&t=453s
Your body releases interferon which is also triggered by the body during viral attacks to shut down the replication ability of the surrounding cells and stop infections.
After 72 hours or more fasted, your body actually recycles large numbers of immune bodies and creates new ones, rejuvenating your entire system.
When you fast, this stimulates apoptosis in senescent or genetically damaged cells. This kills these cells off completely. Senescent cells are responsible for the effects of aging and are the root cause of the development of cancer. If it were possible to destroy them all it would completely stop aging and cancer. That is not possible but fasting can help limit these effects by killing off many of the affected cells and limiting the future effects of aging.
Fasting also releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth, helping a great deal with diseases like MS, peripheral neuropathy and Alzheimers.
In fact, the biochemical precursor to BDNF is beta-hydroxybutyrate, which is the same ketone the body produces to nourish the brain while fasting.
Autophagy induced by fasting even helps hair regrow.
What breaks a fast? https://www.youtube.com/watch?v=7aRLsCpxy3o&t=2s
Dieters losing weight through intermittent fasting show greater reduction in waist size and increase in insulin sensitivity for the same weight lost and alternate day fasters were shown to lose fat while gaining muscle at the same time over a six month period.
Fasting has been shown to increase bone marrow volume by 10% and levels of carnosine in the body in as little as a few weeks.
Fasting also increases telomere length, negating some of the effects of aging at a cellular level.
Eating one meal a day can bring most of these benefits to a lesser degree, and adding a few entire days off from eating per week will have even more effect especially when starting to feel poorly.
Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia.
Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or certain forms of hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis. Those with Addison’s disease may also be unable to fast without liberal use of exogenous ketones, depending on severity. If you experience extreme symptoms of some kind, especially dizziness then simply break the fast and seek advice.
Resources:
https://pubmed.ncbi.nlm.nih.gov/6859089/
https://www.ncbi.nlm.nih.gov/pubmed/23876457
https://repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations
https://www.cell.com/cell/fulltext/S0092-8674(19)30849-9
https://www.ncbi.nlm.nih.gov/pubmed/25686106
https://www.ncbi.nlm.nih.gov/pubmed/24905167
https://www.ncbi.nlm.nih.gov/pubmed/10859646
http://www.sciencedirect.com/science/article/pii/S0005272806000223
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7
https://www.ncbi.nlm.nih.gov/gene/25712
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/
https://www.ncbi.nlm.nih.gov/pubmed/10232622
https://academic.oup.com/ajcn/article/81/1/69/4607679
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/
https://www.sciencedirect.com/science/article/pii/S1931312809002832
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/
https://www.nejm.org/doi/full/10.1056/NEJMc2001176
https://pubmed.ncbi.nlm.nih.gov/23408502/
https://pubmed.ncbi.nlm.nih.gov/27569118/
https://pubmed.ncbi.nlm.nih.gov/21410865/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/
https://www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf
https://www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext
https://pubmed.ncbi.nlm.nih.gov/20921964/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10
https://www.biorxiv.org/node/93305.full
https://pubmed.ncbi.nlm.nih.gov/25909219/
https://clinical.diabetesjournals.org/content/36/3/217
https://europepmc.org/article/MED/22402737?javascript_support=no
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x
https://www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/
https://www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart
https://holistickenko.com/vitamin-d-kidney-liver-disease/
This list compiled over months of research by the user known as Pottenger’s Human on youtube but feel free to copy and paste this anywhere you like, no accreditation needed!
Amazing research. Thanks.
Great info! Glucose goal 83…
So much information! Thankful even if I’ll have to listen to it five times to absorb it!!! Very much appreciated…
Bravo Dr. Lenzkes regarding the comment about sponsors. And thanks to all the Doctors.
Happy about the discussion about the carnivore diet in relation to diabetes, would love for more research to be done to understand these bio markers on a carnivore diet.
Everything in moderation,
correct my a1c 5.2 but my glucose levels over 100 fasting 😢 every day
Pathologist Associate Professor Ken Sikaris pointed out this increase in A1C noticed in keto/carnivore types. He postulated from the blood work he has seen that this is of little concern as the item they are measuring in these tests tends to not be destroyed in the normal span but survive much longer. So normal span would be 90-120 days for end of life for hemoglobin but over time the lifespan increases of these cells.and would mean longer period of time exposed to glucose increasing the A1C score.